Производство моноклональных антител FiberCell HFBR:
Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development: Okada, T. et al; Nature Scientific Reports, Jun 2019, vol 9(1) pg: 8625 [Open Access]
A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition: Moorman, C.D. et al; Front Immunol. 2018; 9: 3119. [Open Access]
Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7: Bang,S., Yoo, J., Gong, X. ; Neuroscience Bulletin 2018 Jan 1-20 [Abstract]
Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis: Tati, S. et al.; Neoplasia,2017 19:716-733 [Open Access]
Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2-/- mice.: Ghosh, D. et al.; J Leukoc Biol. 2016 Oct;100(4):747-760 [Abstract]
IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis: Wang,D. et al; J. Immunol., 2016; 197: 2992 – 3007 [Abstract]
A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells: Weber, T. et al; Journal of Immunology Research Volume 2015 (2015), Article ID 561814. [Open Access]
A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK : Halford, M.M. et al; PLOSone 2013. [Open Access]
Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody: Krawczyk, A. et al.; 2013 100 (17): 6760-6765 [open access] [materials and methods]
GRB2 Interaction with the Ecotropic Murine Leukemia Virus Receptor, mCAT-1, Controls Virus Entry and Is Stimulated by Virus Binding: Chen, Z. et al; J Virol. 2012 Feb; 86(3): 1421–1432. [Open Access]
Human monoclonal antibodies to West Nile virus identify epitopes on the prM protein: Calvert, A.E. et al; Volume 410, Issue 1, Pages 30-37. [Open Access]
Contemporary Seasonal Influenza A (H1N1) Virus Infection Primes for a More Robust Response To Split Inactivated Pandemic Influenza A (H1N1) Virus Vaccination in Ferrets: Ellebedy,A.; Clin Vaccine Immunol December 2010 vol. 17 (12) 1998-2006 [Open Access]
Cell-free Assays for HIV-1 Uncoating: Aiken, C; Methods Mol Biol. 2009; 485 [Open Access]
Human antibodies for immunotherapy development generated via a human B cell hybridoma technology: Li, J; PNAS. 2006; 103(10)[Open Access]
Выделение и производство белков:
Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions.:Rattila, S. et al. ; Cells. 2019 Oct 31;8(11) [Open Access]
Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity:Cui, X. et al; Int J Mol Sci. 2019 Jul; 20 (13):3158 [Open Access]
Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase: Maheshwari et al.; Nature Communications Biology volume 1, Article number: 74 (2018) [Open Access]
Novel trimeric human cytomegalovirus glycoprotein B elicits a high-titer neutralizing antibody response: Cui, X et al.; Vaccine 2018 36(37):5580-5590 [Open Access]
Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis: Tati, S. et al.; Neoplasia,2017 19:716-733 [Open Access]
PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway: Jones, K. et al. PLOSone 2016 July [Open Access]
Rabbits immunized with Epstein-Barr virus gH/gL or gB recombinant proteins elicit higher serum virus neutralizing activity than gp350: Cui, X. et al. Vaccine. 2016 Jul 25;34(34):4050-5 [Open Access]
Kinetic and Spectroscopic Study of Peptidylglycine Monooxygenase: Chauhan,S.. 2016 [Open Access]
Antigenicity and Immunogenicity of a Trimeric Envelope Protein from an Indian Clade C HIV-1 Isolate: Priya, R.S. The Journal of Biological Chemistry 2015 290: 9195-9208 [Open Access]
A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells: Weber, T. et al; Journal of Immunology Research Volume 2015 (2015), Article ID 561814. [Open Access]
Induction and Activation of Latent Transforming Growth Factor-β1 Are Carried out by Two Distinct Domains of Pregnancy-specific Glycoprotein 1 (PSG1): Ballesteros, A. et al.; The Journal of Biological Chemistry 2015 290: 4422-4431 [Open Access]
Better and faster: improvements and optimization for mammalian recombinant protein production: Almo,S., Love, J.; Curr Opin Struct Biol 2014 ; 26: 39–4 [Open Access]
Efficient production and purification of recombinant human interleukin-12 (IL-12) overexpressed in mammalian cells without affinity tag: Jayanthi S. et al.; Protein Expr Purif. 2014 Oct; 102: 76–84. [Open Access]
Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12–like Heterodimers Extracellularly: Abdi, K. et al.; The Journal of Immunology 2014 192 (12): 6028-6036 [Open Access]
A novel tetrameric gp350(1-470) as a potential Epstein-Barr virus vaccine: Cui,X. et al.; Vaccine 2013 31(30): 3039-3045 [Open Access]
The HHM Motif at the CuH-site of Peptidylglycine Monooxygenase is a pH-Dependent Conformational Switch: Kline, C.D. et al, Biochemistry 2013 52(15): 2586–2596
[Open Access]
Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody: Krawczyk, A. et al.; 2013 100 (17): 6760-6765 [open access] [materials and methods]
Cloning, Expression, and Functional Characterization of TL1A-Ig:
Khan, S. et al.; The Journal of Immunology 2013 190 (4): 1540-1550 [Open Access]
Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques: Kulkarni, V. et al.; Human Vaccines & Immunotherapeutics Vol 9, 2013 (10). [Open Access]
Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15•IL-15Rα Cytokine Compared to IL-15 Monomer: Chertova, E. et al.; The Journal of Biological Chemistry 2013 288: 18093-18103. [Open Access]
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum: Bergamaschi, C.. et al.; Blood 2012 120 (1) [Open Access]
Antiviral Breadth and Combination Potential of Peptide Triazole HIV-1 Entry Inhibitors: McFadden, K. et al.; Antimicrob. Agents Chemother. 2012 56 (2): 1073-1080 [Open Access]
T Cell Costimulation by TNFR Superfamily (TNFRSF)4 and TNFRSF25 in the Context of Vaccination: Schreiber, T. et al.; The Journal of Immunology 2012 189 (7): 3311-3318 [Open Access]
Proteolytic processing of vascular endothelial growthfactor-D is essential for its capacity to promote the growth and spread of cancer: Harris N.C. et al.; The Faseb Journal 2011 pp. 2615-2625. [Open Access]
Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3: Han, L. et al.; Cell 2010 143(3):404-15 [Open Access]
1.8 Å structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells: Kausik Chattopadhyay et al.; Acta Crystallogr D Biol Crystallogr.2009; 65(Pt 5): 434–439. [Open Access]
Purification and characterization of recombinant human renin for X-ray crystallization studies: Wu, Z. et al.; BMC Biochemistry 2008 9:19 [Open Access]
Murine Pregnancy-Specific Glycoprotein 23 Induces the Proangiogenic Factors Transforming-Growth Factor Beta 1 and Vascular Endothelial Growth Factor A in Cell Types Involved in Vascular Remodeling in Pregnancy: Wu JA et al., Biol Reprod. 2008 Dec;79(6):1054-1061 [Open Access]
Expression of SEAP (secreted alkaline phosphatase) by baculovirus mediated transduction of HEK 293: Jardin BA et al., J Biotechnol. 2008 Jun 30;135(3):272-80. [Abstract]
Purification of soluble CD14 fusion proteins and use in an electrochemiluminescent assay for lipopolysaccharide binding: Burkhardt, M. et al., Protein Expr Purif. 2007 Jan;51(1):96-101 [Abstract]
Recombinant-protein production in insect cells utilizing a hollow-fibre bioreactor: Baxter SC et al., Biotechnol Appl Biochem. 2006 Nov;45(Pt 3):167-72. [Abstract]
Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein. Implications for therapeutic and vaccine strategies: Arthos, J.; Cicala, C et al., JBC 2002;277(13):11, 456-464 [Open Access]
Alteration of Hepatitis A Virus (HAV) Particles by a Soluble Form of HAV Cellular Receptor 1 containing the Immunoglobulin- and Mucin-Like Regions: Silverstein, E., Journal of Virology, 2003 p. 8765-8774 [Open Access]
Производство экзосом:
Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury: Cao et al; Stem Cell Research and Therapy (2020) 11:206 [open access]
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications: Tsiapalis, D. & O’Driscoll, L.; Cells 2020, 9, 991[open access]
Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity: Litao Yan & Xing Wu; Cell Biol Toxico (Dec 09 2019) [open access]…
Urine-derived stem cells facilitate endogenous spermatogenesis restoration of busulfan-induced non-obstructive azoospermic mice by paracrine exosomes. Cuncan DengYun Xie et al.; Stem Cells and Development (Jul 16 2019) [abstract]…
Extracellular Vesicles From Human Urine-Derived Stem Cells Ameliorate Erectile Dysfunction in a Diabetic Rat Model by Delivering Proangiogenic MicroRNA: Ouyang B. et al.; Sexual Medicine (2019) [open access]...
Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift: Park, JE et al.; Oncogene (2019) [abstract] ...
Large-scale preparation of extracellular vesicles enriched with specific micro-RNA: Yoo, KW et al. ; Tissue Engineering. 2018 [abstract]
Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes: Watson,D.C. et al.; J Extracell Vesicles. 2018 Feb 28;7(1) [open acccess]
Use of a Hollow Fiber Bioreactor to Collect Extracellular Vesicles from Cells in Culture: Yan IK et al.; Methods Mol Biol. 2018;1740:35-41 [abstract]…
Clinical Scale Production and Wound Healing Activity of Human Adipose Derived Mesenchymal Stem Cell Extracellular Vesicles from a Hollow Fiber Bioreactor. [Fibercell Poster ISEV2017]
Efficient production and enhanced tumor delivery of engineered extracellular vesicles: Watson DC et al.; Biomaterials 105, 2016: 195-205 [open access]…
In vitro toxicology studies of extracellular vesicles: Maji,S. et al.; Journal of Applied Toxicology (2016) [abstract]
Comparative Secretome Analyses Using a Hollow Fiber Culture System with Label-Free Quantitative Proteomics Indicates the Influence of PARK7 on Cell Proliferation and Migration/Invasion in Lung Adenocarcinoma: Ying-Hua Chang et al, J. Proteome Res. 2012, 11, 11, 5167-5185 [abstract]
Получение 3D культур секретома:
Secretomic profiling of cells from hollow fiber bioreactor reveals PSMA3 as a potential cholangiocarcinoma biomarker: Verathamjamras,C. et al; Int J Oncol. 2017 51(1):269-280. [Abstract]
Analysis of colorectal cancer glyco-secretome identifies laminin Beta-1 (LAMB1) as a potential serological biomarker for colorectal cancer: lIN,Q. et al.; Proteomics 2015, 15, 3905–3920 [Abstract]
Effective enrichment of cholangiocarcinoma secretomes using the hollow fiber bioreactor culture system: Weeraphan, C.; Talanta. 2012 Sep 15;99:294-301 [Abstract]
Collection of in vivo-like liver cell secretome with alternative sample enrichment method using a hollow fiber bioreactor culture system combined with tangential flow filtration for secretomics analysis: Wen,Y-T et al.; Analytica Chimica Acta 2011 Vol. 684, p81-88 [Abstract]
Cell Secretome Analysis Using Hollow Fiber Culture System Leads to the Discovery of CLIC1 Protein as a Novel Plasma Marker for Nasopharangeal Carcinoma: Chang,YH et al.; J Proteome Res. 2009 8(12):5465-74. [Abstract]
Proteomics Analysis of Nasopharyngeal Carcinoma Cell Secretome Using a Hollow Fiber Culture System and Mass Spectrometry: Wu, HJ et al.; Journal of Proteome Research, 2009,8 (1), 380-389 [Open Access]
Производство вирусных частиц:
High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals: Pihl, A. et al., Nature Scientific Reports volume 8, Article number: 17505 (2018) [Open Access]
Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model: Camilly P. Pires de Mello et al.; Antimicrob Agents Chemother 2018 62 [abstract]
Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system: Pires de Mello, C.P.; European Journal of Pharmaceutical Sciences 111 (2018) 443-449 [open access]
Antiviral Effects of Clinically-Relevant Interferon-alpha and Ribavirin Regimens against Dengue Virus in the Hollow Fiber Infection Model (HFIM): Pires de Mello, C.P. et al; Viruses 2018, 10, 317 [open access]
Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor: Tapia, F. et al.; Vaccine 2014 Feb 12;32(8):1003-11 [Open Access]
Considerations in Scale-Up of Viral Vaccine Production: William G. Whitford and Alain Fairbank; BioProcess International 2011 September [PDF]
Effect of Half-Life on the Pharmacodynamic Index of Zanamivir against Influenza Virus Delineated by a Mathematical Model: Brown, A. et al.; Antimicrob. Agents Chemother. 2011 55 (4) 1747-1753[open access]
Antiviral pharmacodynamics in hollow fibre Bioreactors: McSharry, J. et al.; Antiviral Chemistry & Chemotherapy 2011; 21:183–192 [open access]
A Hollow fiber bioreactor for expanding HIV-1 in human lymphocytes used in preparing an inactivated vaccine candidate: Leong M, Bobbitt W, Vyas G, Biologicals, 2007 35 (4):227-233.
Работа c эндотелиальными клетками:
Application of a Flow-Based Hollow-Fiber Co-Culture System to Study Cellular Influences under Hyperglycemic Conditions: Ebrahim, A.S. et al; Nature Scientific Reports [open access]
Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration: Pasikowska, M. et al; Blood 2016 128:563-573
Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia: Walsby, E. et al.; Blood 2014 123:3607-3617 [open access]
PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium: Noel,J. et al.; Am J Physiol Lung Cell Mol Physiol. 2013 305(11): L805–L818. [open access]
Transcriptional Remodeling of Ion Channel Subunits by Flow Adaptation in Human Coronary Artery Endothelial Cells: Kefaloyianni, E. and Coetzee, W.A.; J Vasc Res. 2011; 48(4): 357–367. [open access]
Endothelial Cell Capture of Heparin-Binding Growth Factors under Flow: Zhao, B. et al.; PLOS Computational Biology, 2010. [open access]
CAVEOLAE ARE AN ESSENTIAL COMPONENT OF THE PATHWAY FOR ENDOTHELIAL CELL SIGNALING ASSOCIATED WITH ABRUPT REDUCTION OF SHEAR STRESS: Milovanova, T. et al.; Biochim Biophys Acta. 2008 1783(10): 1866–1875. [open access]
Lung Ischemia: A Model for Endothelial Mechanotransduction: Chatterjee, S. et al.; Cell Biochem Biophys.2008; 52(3) [open access]
Advanced methods of adenovirus vector production for human gene therapy: roller
bottles, microcarriers, and hollow fibers: T. Isayeva, et al.; BioProcessing Journal 2003 75-81 [PDF]
Создание инфекционных моделей in-vitro для исследования PK/PD:
Modeling of Effective Antimicrobials to Reduce Staphylococcus aureus Virulence Gene Expression Using a Two‐Compartment Hollow Fiber Infection Model: Shukla, S.K. et al Toxins vol. 12 (2) 2020 [open access]
The Effect of Drug Combinations on the Kinetics of the Emergence of Antibiotic Resistance in E. coli CFT073 Using the In Vitro Hollow Fiber Infection Model: Garimella, N. et al, Antimicrobial Agents Dec 2019 [abstract]
Fluconazole Monotherapy Is a Suboptimal Option for InitialTreatment of Cryptococcal Meningitis Because of Emergenceof Resistance: Hope, W. et al, Therapeutics and Preventation Nov-Dec 2019 [open access]
Mimicking in-vivo exposures to drug combinations in-vitro: antituberculosis drugs in lung lesions and the hollow fiber model of infection: Kloprogge, F. et al, www.nature.com/scientificreports 13 Sep 2019 [open access]
P-glycoprotein mediated efflux reduces the in vivo efficacy of a therapeutic targeting the gastrointestinal parasite Cryptosporidium: Arnold SLM et al; J Infect Dis. 2019 Jun 8. [open access]
Pharmacodynamics of 1 Ceftazidime plus Avibactam against KPC-2 Bearing Isolates of Klebsiella pneumoniae in a Hollow Fiber Infection Model: Drusano GL et al; Antimicrob Agents Chemother. 2019 Jun 3 [abstract]
Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans: Antimicrobial Agents and Chemotherapy May 2019 Vol 63 Issue 5 [open access]
Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus: Broussou, D. et al; PLOS ONE Jan 2019 [open access]
Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model: Camilly P. Pires de Mello et al.; Antimicrob Agents Chemother 2018 62 [abstract]
Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model: Broussou, D. et al; Front. Microbiol., 27 March 2018 [open access]
Optimization and evaluation of piperacillin plus tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modelling: Yadav, R. et al; AMS 2018 (62) 3 [abstract]
Evaluation of Activity and Emergence of Resistance of Polymyxin B and ZTI-01 (Fosfomycin for Injection) against KPC-Producing Klebsiella pneumoniae: Diep, J.K. et al; Antimicrob. Agents Chemother. 2018 (62) 2 [open access]
Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system: Pires de Mello, C.P.; European Journal of Pharmaceutical Sciences 111 (2018) 443-449 [open access]
Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era. Bulman Z.PP; mBio 8(4)2017 [open access]
In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing Escherichia coli in a hollow-fibre infection model Soon, R et al. International Journal of Antimicrobial Agents 2017 49(1)[open access]
From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling. Drusano G.L.; Bioorg Med Chem. 2016[abstract]
Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps: Deshpande, D. et al.; Clin Infect Dis. 2016, 63 (3)S80-87 [abstract]
Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo: Deshpande, D. et al.; Clin Infect Dis. 2016, 63 (3): S88-S94.[open access]
A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way: Deshpande, D. et al.; Clin Infect Dis. 2016, 63(3): S95-S101.: S88-S94.[open access]
Thioridazine as Chemotherapy for Mycobacterium avium Complex Diseases: Deshpande, D. et al.; Antimicrob. Agents Chemother. 2016 60 (8) 4652-4658 [open access]
Azithromycin Pharmacodynamics Against Non-Typeable H. Influenzae: Fisher, J., Yale University Public Health Theses 2016 [open access]
EMA Qualification opinion: In-vitro hollow fiber system model of tuberculosis (HSF-TB): EMA/CHMP/SAWP/47290/2015
Continuous culture of Cryptosporidium parvum using hollow fiber technology: Morada, M. et al.; Int J Parasitol. 2016 Jan;46(1):21-9 [related presentation PDF]
A long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies: Srivastava, S. et al.; EBioMedicine 2016; 6:126-138 [open access]
Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy: Brown, A. et al.; mBio vol. 6 (6) [open access]
Strategic Regulatory Evaluation and Endorsement of the Hollow Fiber Tuberculosis System as a Novel Drug Development Tool: Romero, K., Clay, R. and Hanna, D.; Clinical Infectious Diseases 2015 61 (1): S5–9 [open access]
Pharmacokineticdeterminants of virological response to raltegravir in thein vitropharmacodynamic hollow-fiber infection model system: Brown AN, Adams JR, Baluya DL, Drusano G; . Antimicrob AgentsChemother 59:3771–3777 [open access]
In Vitro Pharmacodynamics of Various Antibiotics in Combination against Extensively Drug-Resistant Klebsiella pneumoniae Lim, Tze-Peng et al.; Antimicrobial Agents and Chemother. 2015 59(5): 2515–2524.[open access]
Correlations Between the Hollow Fiber Model of Tuberculosis and Therapeutic Events in Tuberculosis Patients: Learn and Confirm: Gumbo, T.;2015 [open access]
The Hollow Fiber Infection Model: Principles and Practice: Cadwell, J.;J Adv Antibiotics and Antibodies 2015, 1(1) [open access]
Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance:Ly,N.S. et al.; Journal of Antimicrobial Therapy 2015 70(5): 1434-1442 [open access]
Hollow Fiber System Model for Tuberculosis: The European Medicines Agency Experience: Cavaleri, M. and Manolis, E.; Clin Infect Dis. (2015) 61 (suppl 1): S1-S4.[open access]
Rapid Drug Tolerance and Dramatic Sterilizing Effect of Moxifloxacin Monotherapy in a Novel Hollow-Fiber Model of Intracellular Mycobacterium kansasii Disease: Srivastava, S. et al.; Antimicrob. Agents Chemother. 2015, 59(4) [open access]
Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy: Bakshi R., Shapiro A. et al.; Science Translational Medicine 2013:Vol. 5, Issue 205 [open access]
Thioridazine Pharmacokinetic-Pharmacodynamic Parameters “Wobble” during Treatment of Tuberculosis: a Theoretical Basis for Shorter-Duration Curative Monotherapy with Congeners Musuka, S. et al.; Antimicrob. Agents Chemother. 2013 vol. 57 no. 12 5870-5877 [open access]
PK/PD models in antibacterial development: Velkov, T. et al.; Curr Opin Microbiol . 2013, 16(5) [open access]
Hollow-fiber pharmacodynamics studies and mathematical modeling to predict the efficacy of amoxicillin for anthrax postexposure prophylaxis in pregnant women and children. Louie, A et al.; Antimicrob Agents Chemother 2013; 57:5946–60. [open access]
Relationship between Ceftolozane-Tazobactam Exposure and Drug Resistance Amplification in a Hollow-Fiber Infection Model: VanScoy, B. et al.; Antimicrobial Agents and Chemotherapy 2013 p 4134 – 4138. [open access]
The Hollow Fiber Infection Model for Antimicrobial Pharmacodynamics and Pharmacokinetics: Cadwell, J.; Adv Pharmacoepidem Drug Safety 2012 [open access]
In Vitro Activity of MK-7655, a Novel Beta-Lactamase Inhibitor, in Combination With Imipenem Against Carbapenem-Resistant Gram-Negative Bacteria: Hirsch,E.B. et al.; Antimicrobial Agents and Chemotherapy 2012; 56(7): 3753–57 [open access]
Simulated Antibiotic Exposures in an In Vitro Hollow-Fiber Infection Model Influence Toxin Gene Expression and Production in Community-Associated Methicillin-Resistant Staphylococcus aureus Strain MW2: Pichereau, S. et al.; Antimicrob Agents Chemother. 2012 Jan; 56(1): 140–147. [open access]
Effect of Half-Life on the Pharmacodynamic Index of Zanamivir against Influenza Virus Delineated by a Mathematical Model: Brown, A. et al.; Antimicrob. Agents Chemother. 2011 55 (4) 1747-1753[open access]
Antiviral pharmacodynamics in hollow fibre Bioreactors: McSharry, J. et al.; Antiviral Chemistry & Chemotherapy 2011; 21:183–192 [open access]
Pharmacokinetic Mismatch Does Not Lead to Emergence of Isoniazid- or Rifampin-Resistant Mycobacterium tuberculosis but to Better Antimicrobial Effect: a New Paradigm for Antituberculosis Drug Scheduling: Srivastava, S. et al; Antimicrob. Agents Chemother. 2011 55 (11): 5085-5089 [open access]
Moxifloxacin Pharmacokinetics/Pharmacodynamics and Optimal Dose and Susceptibility Breakpoint Identification for Treatment of Disseminated Mycobacterium avium Infection :Deshpande,D. et al.;Antimicrob Agents Chemother. 2010 54(6): 2534–2539. [open access]
Optimizing the Culture of Plasmodium Falciparum in Hollow Fiber Bioreactors :Preechapornkul,P. et al.;Southeast Asian J Trop Med Public Health. 2010 41(4): 761–769 [open access]
Ethambutol Optimal Clinical Dose and Susceptibility Breakpoint Identification by Use of a Novel Pharmacokinetic-Pharmacodynamic Model of Disseminated Intracellular Mycobacterium avium: <>Deshpande, D. et al.; Antimicrob Agents Chemother. 2010 54(5): 1728–1733 [open access]
In Vitro System for Modeling Influenza A Virus Resistance under Drug Pressure: Brown, A.; Antimicrob Agents Chemother. 2010 Aug;54(8):3442-50 open access]
Prediction of the Pharmacodynamically Linked Variable of Oseltamivir Carboxylate for Influenza A Virus Using an In Vitro Hollow-Fiber Infection Model System. McSharry, J.; Antimicrob. Agents Chemother. 2009 53 (6) 2375-2381 open access]
Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System. McSharry, J.; Antimicrob. Agents Chemother. 2009 53(1) 129-135 [open access] – system diagram
Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for Bacillus Anthracis?Drusano GL et al. 2008 Antimicrob Agents Chemother 52 (11), 3973- [open access]
Pharmacodynamic Characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system. Kirstein MN, Brundage RC, Moore MM, Williams BW, Hillman LA, et al. 2008 Cancer Chemother Pharmacol 61: 291-299.
Comparative Pharmacodynamics of Gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa: Tam, V. et al; Antimicrob Agents Chemother. 2006 50(8): 2626–2631
Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling. Gumbo, T. et al.; J Infect Dis. 2004 Nov 1;190(9):1642-51. [open access]
